Two-dimensional Mass Spectrometry in a Linear Quadrupole Ion Trap using Ion Micropacket Detection

The frequency tagging 2D MS method is a methodology for operating a mass spectrometer. It provides a rapid way to recognize a sample as belonging to a particular functional group class or containing a component that has particular structural features evident from the product ion spectra. However, low kHz beat frequencies were observed under this method, which reduced mass resolutions. In order to improve the resolution, the beats must be measured for a longer period of time, or a higher frequency must be measured.

Researchers at Purdue University have developed a highly efficient method of gathering data from the 2D MS/MS domain on a single linear quadrupole ion trap using simple frequency scanning technology. This technology helps mass spectrometrists and mass spectrometer users who want to efficiently analyze a chemical sample by mass spectrometry. Their use of a micropacket technique, offers higher resolution, reduced harmonic overlap, and fewer scans to populate the MS/MS domain.

Advantages:

-Highly efficient

-High resolution

-Reduced harmonic overlap

Potential Applications:

-Ion traps

-Miniature instruments

-Multi-analyzer instruments

TRL: 4

Intellectual Property:

Keywords: Frequency tagging 2D MS, mass spectrometer, 2D MS/MS domain, linear quadrupole ion trap, frequency scanning technology, micropacket technique, high resolution, reduced harmonic overlap, ion traps, miniature instruments, 2D MS, Chemical Engineering, Chemistry and Chemical Analysis, MS/MS, Quadrupole Ion Trap, Tandem Mass Spectrometry, Two-dimensional Mass Spectrometry