Suspension-based Oral Solid Doses

Oral solid doses constitute approximately 60% of drug products. Oral solid dose manufacturing must deal with challenges associated with powder rheology; this is problematic for micronized powders which are cohesive. Poorly water-soluble compounds constitute 40% of currently marketed compounds. Particle size reduction is used to improve drug bioavailability, but causes rheological problems in manufacturing. The lack of constitutive equations leads to a demand for an effective precision dosing process.

Researchers at Purdue University have developed a new micron-scale powder process. This process enables accuracy dosing of drug mass and low product relative standard deviation; additionally, the method allows for specification of particle size distribution in a product by choice of source material, as experiments have demonstrated that particle size is preserved through the printing process.

Advantages:

-Versatile processing of fine particles

-Low relative standard deviation

-Enables production of high-dose pharmaceuticals

Potential Applications:

-Compounding pharmacy

-Slurry printing

TRL: 4

Intellectual Property:

Keywords: micron-scale powder process, precision dosing, drug mass dosing, low relative standard deviation, fine particle processing, high-dose pharmaceuticals, compounding pharmacy, slurry printing, oral solid doses, powder rheology