Novel Approach to Induce Protection against Respiratory Viruses
Activates innate immune cells to trigger rapid antiviral protection, boosting CD8 T-cell response and survival.
Researchers at Purdue University have developed a new method for protecting against respiratory viruses by activating inherent immune response. The technique is virus-specific, promoting adaptation to specific viral strands such as influenza, SARS-CoV-2, respiratory syncytial virus (RSV), and others. This innovative method has been tested in vitro with human innate lymphoid cells (ILC) as well as in mice in vivo, exhibiting strong CD8 T-cell response. By increasing ILC response in the lungs of mice, a 60% survival rate was observed. Vaccination kits can be created using these results to protect against respiratory viruses.
Technology Validation:
-In vivo testing on mice
-In vitro testing on human ILC cells
Advantages:
-Rapid Immune Response
-Improved Survival Rate in Mice
Potential Applications:
-Virus Research
-Biotechnology
-Vaccinations
TRL: Biotechnology
Intellectual Property:
Provisional-Gov. Funding, 2020-08-27, United States
Utility-Gov. Funding, 2021-08-24, United States
Keywords: Anti-Virus, Biotechnology, Cell Biology, Coronavirus, Drug Development, Drug Discovery, Influenza, Respiratory, Respiratory Disease, Therapeutics, Vaccines, Virus