Nano-composite Microparticles with Ivacaftor and Colistin

Intravenous and oral antibiotics are not always effective for lung infections due to limited drug exposure at the infection site and bacterial resistance.

Researchers at Purdue University have developed a novel combination therapy of polymyxins for treating bacterial lung infections. Polymyxins have often been used as the last-line resort for infections caused by multi-drug resistant Gram-negative 'superbugs'; but Inhaled polymyxins can cause toxicity in the lungs. The novel formulation developed by Purdue researchers creates a powerful therapeutic option with better antibacterial killing and much-reduced toxicity than the polymyxins alone. The Purdue dry powder formulation shows promise as an inhaled therapy, with satisfactory stability and high aerosolization performance. This innovative inhalation formulation promises a life-saving option for patients suffering from bacterial lung infections, including people infected by multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Enterobacterales.

Advantages:

-Enhanced efficacy

-Decreased drug resistance

-Decreased toxicity

Potential Applications:

-Pharmaceuticals

-Biomedical

-Medicine

Related Publication:

Inhalable Nanocomposite Microparticles with Enhanced Dissolution and Superior Aerosol Performance

Mol. Pharmaceutics, Published online July 24, 2020

https://doi.org/10.1021/acs.molpharmaceut.0c00390

TRL: 3

Intellectual Property:

Keywords: Intravenous, oral antibiotics, lung infections, drug exposure, bacterial resistance, novel combination therapy, polymyxins, multi-drug resistant, Gram-negative, superbugs, inhaled polymyxins, toxicity, antibacterial killing, dry powder formulation, inhaled therapy, aerosolization performance, Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacterales, enhanced efficacy, decreased drug resistance, decreased toxicity, pharmaceuticals, biomedical, medicine