Magnetic Nanoparticle Treated Implantable Catheter for Hyperthermic Cell Clearance

At present, central venous access devices have a high failure rate due to cellular obstructions or thrombus formation that can be lethal for patients. For conditions, such as hydrocephalus, a method to resolve these issues is in situ recanalization after revision surgery and in-patient neurosurgery, while for central venous access, there needs to be full replacement of these devices. Often times, patients need to be concomitantly treated with blood thinners, antibiotics, and other drugs that have other side effects. Therefore, both processes can be costly, risky, and painful for patients.

To resolve such issues, researchers at Purdue University have looked at the well-known technique of magnetic nanoparticle induced hyperthermia for treatment of cancer cells and used this method to coat or infuse magnetic nanoparticles on implantable catheters. This would induce localized heat (hyperthermia) using external magnetic fields and help to remove or prevent cellular occlusion at the site of these catheters that are used for various medical procedures. This technology would also reduce the need for revision surgery or replacement of devices and can be used in situ and activated non-invasively, making it much safer and cost-effective.

To view a video related to this technology, click on this link: https://youtu.be/ooCUSTkPGfk

Advantages:

-Induces localized heat (hyperthermia)

-Removes/prevents cellular occlusion

-Reduces need for surgery and replacement of devices

Potential Applications:

-Implantable devices

-Medical/Health

TRL: 6

Intellectual Property:

Keywords: magnetic nanoparticle induced hyperthermia, implantable catheters, cellular occlusion prevention, thrombus formation resolution, central venous access devices, localized heat therapy, non-invasive recanalization, reduced revision surgery, cost-effective medical devices, external magnetic fields