Drying Agents for Rapid Analysis of Whole Blood by Paper Spray Mass Spectrometry
A new methodology significantly reduces the necessary blood drying time for paper spray mass spectrometry from hours to minutes, enabling rapid and convenient high-throughput or point-of-care diagnostics.
Paper spray mass spectrometry has been shown to be a successful method for quantitative and sensitive analysis of pharmaceutical drugs from whole blood. Most current methods, however, involve a drying step that takes at least two hours. This drying time is necessary, otherwise blood runs through the paper during analysis and paper spray mass spectrometry does not function properly.
Researchers at Purdue have developed a drying agent and methodology for paper spray mass spectrometry that reduces drying time to two to five minutes. This method will make a potential point-of-care or high-throughput device more rapid and convenient to use.
Advantages:
-Reduces drying time
-Faster results
-Easier to use
Potential Applications:
-Mass spectrometry
-Blood analysis
TRL: 3
Intellectual Property:
Provisional-Patent, 2011-06-03, United States | PCT-Patent, 2012-06-01, WO | NATL-Patent, 2013-12-23, United States | CON-Patent, 2014-10-13, United States | CON-Patent, 2016-01-04, United States | CON-Patent, 2016-11-22, United States | CON-Patent, 2017-09-20, United States | CON-Patent, 2018-08-21, United States | CON-Gov. Funding, 2020-06-18, United States | CON-Gov. Funding, 2021-08-06, United States | CON-Gov. Funding, 2023-03-30, United States | CON-Gov. Funding, 2024-01-31, United States
Keywords: Paper spray mass spectrometry, mass spectrometry, PS-MS, pharmaceutical analysis, whole blood analysis, drying agent, rapid testing, point-of-care device, high-throughput device, blood analysis, Chemistry and Chemical Analysis, Mass Spectrometry