Axially-offset Differential Interference Contrast Correlation Spectroscopy (ADIC-CS)
A fast, accurate, and adaptable noninvasive spectroscopy technique (ACID-CS) enables enhanced measurement of nanoparticle size distributions in fluidic mediums for research and chemical analysis.
Researchers at Purdue University have developed a noninvasive, label-free technique to quantify particle size distributions in suspensions, described as axially offset differential interference contrast correlation spectroscopy (ACID-CS). ACID-CS is more sensitive than traditional spectroscopy techniques such as dynamic light scattering, and unlike current technologies avoids time-dependent intensity fluctuations. ACID-CS enables accurate measurements of nanoparticles in fluidic mediums. The technique was demonstrated with silica beads of known size and will be useful for a myriad of scientific research applications, such as in protein nanocrystal suspensions. ACID-CS is adaptable for existing microscopes or can be readily implemented as its own apparatus.
Advantages:
-Fast
-Accurate
-Adaptable
Potential Applications:
-Research
-Chemical Analysis
TRL: 4
Intellectual Property:
Provisional-Gov. Funding, 2020-07-22, United States | Utility-Gov. Funding, 2021-05-24, United States | CIP-Gov. Funding, 2021-11-04, United States
Keywords: axially offset differential interference contrast correlation spectroscopy, ACID-CS, particle size distribution, suspension quantification, noninvasive technique, label-free technique, dynamic light scattering alternative, nanoparticle measurement, fluidic medium analysis, protein nanocrystal suspensions