Discovery of Potent Anti-Mpro Inhibitors for Covid-19 Treatment
A novel anti-Mpro inhibitor derived from Chloropyridyl ester derivatives offers effective, Remdesivir-comparable antiviral potency against SARS-COV-2, with applications in COVID-19 treatment and vaccine development.
Researchers at Purdue University have discovered that a potent anti-Mpro inhibitor to be used to treat COVID-19. The anti-Mpro inhibitor is derived from Chloropyridyl ester derivatives. These inhibitors have shown that they have a strong antiviral potency against SARS-COV-2 in VERO cells. VERO cells are a lineage of cell cultures that have been derived from the kidneys of an African green monkey. This inhibitor can block COVID-19 in cell culture assay. This technology can be used to create COVID-19 vaccines. It can also be used in the treatment of COVID-19 patients so that it does not further affect them. This approach is just as effective as Remdesivir, a drug that has shown to help treat patients with COVID-19.
Potential Application:
-Treating Covid-19
-Preventing Covid-19
-Covid-19 Vaccines
Technology Validation: Tested in vero cells.
TRL: 3
Intellectual Property:
Provisional-Gov. Funding, 2020-04-10, United States | Provisional-Gov. Funding, 2020-12-01, United States | NATL-Patent, 2021-02-09, Russia | Foreign, Non-PCT, 2021-02-09, Hong Kong | PCT-Gov. Funding, 2021-02-09, WO | NATL-Patent, 2021-02-09, Australia | NATL-Patent, 2021-02-09, Brazil | NATL-Patent, 2021-02-09, Canada | NATL-Patent, 2021-02-09, China | NATL-Patent, 2021-02-09, Europe | NATL-Patent, 2021-02-09, India | NATL-Patent, 2021-02-09, Japan | NATL-Patent, 2021-02-09, Republic of Korea | NATL-Patent, 2021-02-09, Mexico | NATL-Patent, 2022-10-10, United States
Keywords: anti-Mpro inhibitor, Chloropyridyl ester derivatives, COVID-19 treatment, SARS-COV-2, VERO cells, antiviral potency, COVID-19 vaccines, Remdesivir alternative, 3CL protease inhibitors, coronavirus therapeutics