Continuous Flow Synthesis of A2E

Researchers at Purdue University have developed a set of reaction conditions to optimize production of N-Retinylidene-N-retinylethanolamine (A2E). A2E forms lipid deposits in the retinal pigment epithelium, causing vision impairment and blindness in eye conditions such as Stargardt's disease, cone-rod dystrophy, Best's macular dystrophy, and potentially age-related macular degeneration. Synthetic A2E is often used to simulate vision impairment in vitro, providing insights into the mechanisms of these eye conditions. Purdue researchers have modified the conventional one-pot reaction conditions for production of synthetic A2E to optimize yield. In a continuous flow reactor, the researchers obtained an 87-fold reduction in reaction time, from 48 hours to 33 minutes, with an accompanying yield improvement from 49% to 78%.

TRL: Chemistry and Chemical Analysis

Intellectual Property:

Keywords: A2E, Chemistry and Chemical Analysis, Lipid bisretinoid, N-Retinylidene-N-retinylethanolamine